Best Flea & Tick Prevention For Cats in 2022 [*Top Picks*]

Looking for the best flea & tick prevention for cats on the market? We’ve got you covered. Check out our ratings of absolute bestsellers below and make a final decision.

6488 Reviews Scanned

  • Advantage II 6-Dose Large Cat Flea Prevention, Flea Prevention for Cats, Over 9 Pounds
    Bestseller #1
    Advantage II 6-Dose Large Cat Flea Prevention, Flea Prevention for Cats, Over 9 Pounds (386)
      6-month supply of advantage II topical large cat flea prevention Easy-to-apply and pre-measured flea treatment application tubes, fragrance-free and waterproof after 24 hours Advantage II large cat flea prevention kills fleas through contact, meaning fleas don’t have to bite your cat in order to die.Avoid contact with eyes or clothing Starts working within 12 hours and protects your cat for up to 30 days. Kills fleas in multiple life stages; Eggs, larvae and adults to break the flea life cycle Vet recommended, fragrance free and designed specifically to treat and prevent fleas on cats
  • FRONTLINE Plus for Cats and Kittens (1.5 pounds and over) Flea and Tick Treatment, 3 Doses
    Bestseller #1
    FRONTLINE Plus for Cats and Kittens (1.5 pounds and over) Flea and Tick Treatment, 3 Doses (386)
      The #1 name in flea & tick protection trusted by pet owners for over 20 years, this waterproof, fast-acting flea and tick treatment kills fleas, flea eggs, lice, and ticks, including those that may transmit Lyme disease. Designed for use only with cats and kittens, this long-lasting treatment is made for cats eight weeks or older, weighing 1.5 pounds or more. Made with two active ingredients, fipronil and (S)-methoprene, this treatment stops infestations and prevents new ones. Applied on a single point on your pet, the treatment rapidly covers your cat's entire body and deposits in the sebaceous glands. These glands as a reservoir, continuously replenishing the treatment onto your pet, working even if your cat gets wet. One dose of FRONTLINE Plus lasts 30 days.
  • PetArmor Plus for Cats, Flea & Tick Prevention for Cats (Over 1.5 lb), Includes 6 Month Supply of Topical Flea Treatments, white, 6 count
    Bestseller #1
    PetArmor Plus for Cats, Flea & Tick Prevention for Cats (Over 1.5 lb), Includes 6 Month Supply of Topical Flea Treatments, white, 6 count (386)
      EFFECTIVE, WATERPROOF FLEA TREATMENT FOR CATS: PetArmor Plus is a waterproof, flea & tick topical prevention for cats that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application. TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Cats. PetArmor Plus for Cats has a powerful formula that starts to kill fleas within 24 hours. BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation. FLEA AND TICK PROTECTION: PetArmor Plus for Cats flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease). EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months
  • Advantage II Small Cat Flea Treatment, 4-Dose Small Cat Flea Prevention, 5-9 Pounds
    Bestseller #1
    Advantage II Small Cat Flea Treatment, 4-Dose Small Cat Flea Prevention, 5-9 Pounds (386)
      Contains four one-month applications of Bayer Advantage II topical flea prevention and treatment for small cats 5-9 pounds Advantage II works through contact, so fleas don’t have to bite your cat to die This effective flea treatment kills fleas in multiple life stages — eggs, larvae and adults — to break the flea life cycle Easy-to-apply cat flea treatment starts working within 12 hours and protects for up to 30 days Advantage II is vet-recommended, fragrance-free and designed specifically to treat and prevent fleas on cats
  • TevraPet Actispot II Flea Treatment for Small and Medium Cats 5-9 lbs | 6 Doses | Powerful Prevention and Control, Clear
    Bestseller #1
    TevraPet Actispot II Flea Treatment for Small and Medium Cats 5-9 lbs | 6 Doses | Powerful Prevention and Control, Clear (1436)
      POWERFUL FLEA KILLING TREATMENT FOR SMALL AND MEDIUM CATS: TevraPet Actispot II is a waterproof topical for cats that kills fleas, flea eggs, and flea larvae for up to 30 days after each application VET APPROVED FORMULA: TevraPet Actispot II uses Imidacloprid and Pyriproxyfen - the same safe and effective active ingredients found in Advantage II - but costs far less. Every cat deserves veterinarian quality treatment, Actispot II helps you provide the same level of care without breaking the bank FAST ACTING AND LONG-LASTING WITH NO BITING REQUIRED: TevraPet Actispot II REPELS and KILLS fleas on contact, without your cat being exposed to bites. Begins killing within 24 hours of application, and starts repelling immediately. Other oral flea tablets, pills, and chews require that your pet is bitten by a pest before the meds can start working, potentially exposing your kitty to flea borne diseases BREAK THE CYCLE, PREVENT REINFESTATION: Unlike other flea medications that only temporarily control fleas, Actispot II flea treatment stops infestations dead in their tracks by effectively breaking the flea life cycle. Actispot II safely kills flea eggs and larvae to prevent re-infestation so your cat can get on with napping in the sun and strolling or stalking! through the garden EASY-TO-USE, MADE IN AMERICA: We proudly make every dose of Actispot II here in the USA and rigorously test for quality and potency. Each package comes with six 6 easy to apply, fully waterproof topical applications that ensure your friend has safe and reliable flea protection and control for up to six 6 months Age range description: all life stages
  • SENTRY Fiproguard for Cats, Flea and Tick Prevention for Cats (1.5 Pounds and Over), Includes 6 Month Supply of Topical Flea Treatments
    Bestseller #1
    SENTRY Fiproguard for Cats, Flea and Tick Prevention for Cats (1.5 Pounds and Over), Includes 6 Month Supply of Topical Flea Treatments (386)
      CAT FLEA AND TICK CONTROL: SENTRY Fiproguard topical flea and tick prevention for cats kills fleas, ticks and chewing lice for up to 30 days. VET QUALITY FORMULA: SENTRY Fiproguard is a vet-quality formula flea treatment that contains the active ingredient fipronil. FOR KITTENS AND CATS: Flea and tick control can be used on cats and kittens 8 weeks and older, and 1.5 pounds and older. TICK PREVENTION: Fiproguard for cats also kills deer ticks that may transmit Lyme disease. INCLUDES: Six (6) 0.017 fl. oz. applicators, a six month supply of waterproof topical applications for cat flea and tick control. For best results, apply flea & tick treatment for cats directly to dry skin on your cat's back-between the shoulder blades-on a monthly basis.
  • Hartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments
    Bestseller #1
    Hartz UltraGuard Topical Flea & Tick Prevention for Cats and Kittens - 3 Monthly Treatments (386)
      Topical drop formula kills fleas and deer ticks Includes 3 monthly treatments in easy to apply, single dose tubes Repels mosquitoes for 18 days For use on cats and kittens 12 weeks and older weighing 5 pounds and over
  • NEXTSTAR Flea & Tick Topical Prevention for Cats Over 3.5 lbs, 3-Month Supply
    Bestseller #1
    NEXTSTAR Flea & Tick Topical Prevention for Cats Over 3.5 lbs, 3-Month Supply (386)
      STARTS TO KILL FLEAS AND TICKS IN 15 MINUTES: Start your cat's flea and tick protection in just 15 minutes with NEXTSTAR flea and tick treatment for cats. VET STRENGTH FORMULA: This flea and tick preventive formula is available without a prescription. 30-DAY PROTECTION: Easy-to-use topical application that kills fleas and ticks for 30 days. This flea and tick for cats preventive offers long-lasting protection. PREVENTS REINFESTATIONS: NEXTSTAR cat flea treatment kills ticks and stops reinfestations by preventing flea eggs from developing into biting adults. 7-WAY CONTROL: NEXTSTAR Flea & Tick Topical for Cats provides effective cat flea and tick control for 30 days with just one application. This fast-acting waterproof topical kills fleas, ticks, mosquitoes, chewing lice, flea eggs, flea larvae, and prevents the development of flea pupae.
  • Advantage II Flea Prevention for Small Cats, 6-Dose Small Cat Flea Prevention, 5-9 Pounds (Package may vary)
    Bestseller #1
    Advantage II Flea Prevention for Small Cats, 6-Dose Small Cat Flea Prevention, 5-9 Pounds (Package may vary) (386)
      6-month supply of advantage II flea prevention for small cats 5 to 9 pounds Easy-to-apply and pre-measured application tubes, fragrance-free and waterproof after 24 hours Advantage II 6-dose small cat flea prevention kills fleas through contact, meaning fleas don’t have to bite your cat in order to die Starts working within 12 hours and protects your cat for up to 30 days. Kills fleas in multiple life stages; Eggs, larvae and adults to break the flea life cycle Vet recommended, fragrance free and designed specifically to treat and prevent fleas on cats
  • Cheristin for Cats Topical Flea Prevention – Starts Killing Fleas in 30 Minutes, 6 doses
    Bestseller #1
    Cheristin for Cats Topical Flea Prevention – Starts Killing Fleas in 30 Minutes, 6 doses (386)
      MADE JUST FOR CATS - Topical flea treatment and prevention designed just for cats and recommended by veterinarians ONLY 30 MINUTES – Fast-acting formula starts killing fleas in only 30 minutes - faster than Frontline Plus and Advantage II (3) FAST-ACTING RELIEF – Delivers complete flea relief in 12 hours, killing 98-100% of fleas in a controlled study (2) LONG LASTING – A single dose of Cheristin flea prevention lasts for up to 6 weeks -- Monthly application is recommended ROUNDED TIP APPLICATOR - Quick-drying, non-greasy topical solution is gently delivered by a small applicator with a rounded tip ONE SIZE FITS ALL – One dose size for all cats and kittens over 1.8 lbs and 8 weeks old is great for multi-cat families -- Use one applicator per cat LOW ENVIRONMENTAL IMPACT - Active ingredient, spinetoram, received a 2008 Presidential Green Chemistry award for low environmental impact on the agricultural industry (4)
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